Grey’s Anatomy

It ’s the end of an earned run average asMeredith Grey is about to say goodbyeto Grey - Sloan Memorial Hospital to take up a unexampled task in Boston . This all came about after Ellen Pompeo bring out that she would departGrey ’s Anatomyafter star on the show for 19 years to explore other projection . throw that she was the series agonist for so long , fans are naturally ravage to lose one of their buff - preferent theatrical role as they had watched her transform from a young , inexperienced intern to an honour - winning and experienced Chief of Surgery . However , looking at Meredith ’s overall electric discharge , it ’s clean-cut that she has had a pleasant and well - developed arc — something that ca n’t be say for several other character . Whether it ’s because of their action or discrepant writing , there have been a few characters who , at some point , were control to alter for the worse .

10Jackson Avery

With a famous surgeon for a grandad , audiences are introduced to Jackson as a military man who has hard feelings against using his last name to get onwards in his career . Instead , he wants to make it on his own without people favoring him or his family . However , his exit from the series marks a drastic modification that even April taper out .

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Jackson leaves behind his calling to become the nous of his mother ’s foundation to focus on racial inequality in medical specialty . While it ’s for the good of world , it ’s a drastic change to the Jackson , who does n’t want to be handed anything due to his crime syndicate name . It would be more impressive if he worked his way up like he always want .

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9Alex Karev

Alex and Meredith have a beautiful friendshipthat blossoms , especially once Cristina leaves . Over the years , he has huge character maturation to move away from his uncollectible position to become a compassionate , caring man . Unfortunately , his character development is cast out the windowpane with his departure . He leaves his married woman for Izzie and the children she conceived using her frozen embryos with his spermatozoan years prior . Karev ’s divergence feels like a sudden change in his personality that is unsatisfying when he has grown personally and professionally . It does n’t feel like a move Karev would have made when Izzie had stimulate him such emotional convulsion .

8Derek Shepherd

Derek is an especial operating surgeon , but his personal life often gets in the manner of his vocation . His relationship with Meredith began after Addison cheated on him with Mark . He knows what it feels like to be betray on and all the emotions that come with breaking up their man and wife . With sight of plot holes thatmake no sense about Derek , his cheat on Meredith with Renee ( even with just a buss ) marked a wicked change in his character . It seems unlikely that he would put himself in a emplacement to cheat , especially knowing how it feels to be cheated on and when he put marriage on such a high footstall .

7Teddy Altman

Teddy is a spectacular character , but one small thing changes her character : cheating on Owen . She had been in honey with him since their time in the military , and once Teddy eventually gets what she want for years , she ruin it with Tom week before her wedding .

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It feel like a random occurrence thrown in to jump Owen ’s life yet again . With short development , it ’s a terrible modification in the character who was so confident of her feelings for him . Even veil her pregnancy from him is entirely out of character for Teddy . alternatively of possess her feeling , she self - sabotages .

Split image of Alex Karev in blue scrubs with a stethoscope and Miranda Bailey in white lab coat on Grey’s Anatomy

6Amelia Shepherd

Derek and Amelia are one of Grey ’s Anatomy ’s best sibling distich , but they always have their issue . Her brain tumor is supposed to explain years of rash behaviour and hapless decision - making that head to their terrible relationship . However , the worst change in Amelia is that she does n’t exchange after the tumour ’s remotion . Her selfish conduct does n’t get better as Amelia has continued to be indecisive with major aspects of her life . Given that the series may need another go figure to come now that Meredith is leaving , the writers may focus more on rise her character and fixing any issues or plot holes the lover have find .

5Izzie Stevens

Izzie jade her heart on her sleeve . She ’s regularly in trouble for ignoring protocols in favor of ethics . Leaving Grey - Sloan after her scans reveal she ’s not dying of cancer , Izzie listen to Alex and goes for the happier life she deserves . However , the literal Izzie seems unlikely to grant Alex to leave his life behind to come to Kansas and try out again , being a father to the tiddler she had behind his back . It would be different if he were single , but Alex had a wife and life back in Seattle , and Izzie was never that selfish . Until that point , she always exhibited more standard for herself .

4George O’Malley

George ’s personality is all over the place . He ’s depicted as a compassionate MD capable of step up during acute place ( like when he completed operating room in a stalled elevator ) . However , George changes after sleep with Meredith .

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He becomes a terrible person all because she outcry during sexual urge , and he ’s humiliated . Although he ’s previously shown soft with a variety side compared to his coworkers , after the debacle with Meredith , he ’s a different person , and not for the better . He care less about the feelings of others ( as demonstrate when he slumber with Izzie while being married to Callie ) and can be a bit self - centered too .

Jackson at the hospital looking serious in Grey’s Anatomy

3Cristina Yang

Cristina is a brilliant surgeon and very career driven . However , as the serial progresses , she develops a soft side for her friends and care about their well - being . Viewers would even love tobring back Cristina toGrey ’s Anatomy . However , there are moment of helplessness in the series where her case changes and not for the better .

When Izzie has cancer and only secern her , Cristina does everything she can to help to the point she becomes implausibly distracted during solo surgical procedure . It ’s very unlike her personality . Her workplace never suffers due to external circumstances . The change is small but noticeable as someone who steals more exciting affected role and conflict with bedside manner .

2Miranda Bailey

Miranda is introduce as a no - nonsense Doctor of the Church who stays out of the infirmary drama . But , alas , her reference has changed for the worst . Instead of being hateful because she ’s commonplace and overworked , she ’s mean just to be tight . Her volume has amplified , and her egotism has explode to think she ’s always right no matter what . She has a common sense of entitlement to the infirmary alternatively of being a lofty , hard worker . It ’s a electronegative change to the character who used to fetch logical realism to a pack of characters who did n’t live better . She used to strain to teach and go but leans more into domineering .

1Meredith Grey

At the beginning of the serial , Meredith strives to be everything Ellis is n’t . She want to ready herself apart from her female parent ’s shadow and does n’t even like the compare . unluckily , she changes for the bad and step by step becomes her insensate , self-important female parent . She ’s willing to learn , but as she find oneself success in her career , she thinks she ’s a Jesus to medical specialty . After Derek ’s decease , she does the same affair Ellis did and disappear with her shaver or else of plow with her emotions . James Meredith tries so intemperately not to be Ellis that she completely turns into her .

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Alex Karev wearing a suit and smiling on Grey’s Anatomy

Patrick Dempsey as Derek Shepherd looking to the side in Grey’s Anatomy

Teddy Altman (Kim Raver) lost in thought in Grey’s Anatomy

Amelia standing at the hospital and looking pleased

Izzie Stevens wears her blue scrubs and looks around in Grey’s Anatomy

George O’Malley looking serious in Grey’s Anatomy

Cristina Yang on a hospital ward in Grey’s Anatomy

Miranda Bailey smiling on Grey’s Anatomy

Meredith walking through the hospital on Grey’s Anatomy

Grey’s Anatomy